Asthma Allergy Immunology

Asthma Allergy Immunology

2021, Vol 19, Num, 3     (Pages: 174-182)

Atopy and Allergic Diseases Have No Impact on the Severity of COVID-19

Ali CAN 1, Deniz Eyice KARABACAK 1, Can TÜZER 1, Alpay Medet ALİBEYOĞLU 2, Murat KÖSE 2, Semra DEMİR 1, Suna BÜYÜKÖZTÜRK 1, Bahauddin ÇOLAKOĞLU 1, Asli GELİNCİK 1,

1 Department of Internal Medicine, Division of Immunology and Allergic Diseases, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
2 Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

DOI: 10.21911/aai.676
Viewed: 961
Downloaded : 383

Objective: The clinical features of COVID-19 range from asymptomatic disease to severe pneumonia or even death. Therefore, many researchers have investigated the factors that could affect the severity of COVID-19. We aimed to assess the impact of aero-allergen sensitization and allergic diseases on the severity of COVID-19.

Materials and Methods: We included 60 adult patients with symptomatic COVID-19 and allocated them into two groups equal in number as having severe and non-severe COVID-19. We evaluated the demographic features and allergic diseases in addition to clinical, laboratory and radiological findings of COVID-19. Skin prick tests (SPTs) with common aero-allergens, serum total IgE levels and blood eosinophil counts were evaluated 3 months after the patient`s recovery from COVID-19.

Results: The mean age of the patients was 52 ± 11 years and 73.3% of the patients were male. There was no significant difference between the two groups in terms of age, gender, smoking habits, obesity and comorbidities. Although the frequency of sensitization to aeroallergens and the allergic diseases were similar, the history of allergic diseases in the family was higher in the severe group (p<0.001). The polysensitization in SPTs was associated with the presence of a cytokine storm during the infection (p=0.02). Total IgE levels and blood eosinophil counts were not significantly different between the two groups.

Conclusion: The presence of atopy or allergic diseases does not seem to be related to the severity of COVID-19. However, polysensitization and a family history of allergic diseases are more prominent in those having a cytokine storm and severe COVID-19, respectively.

Keywords : COVID-19, atopy, allergic disease, aero-allergen sensitization, cytokine storm