Asthma Allergy Immunology

Asthma Allergy Immunology

2020, Vol 18, Num, 2     (Pages: 098-101)

Retroperitoneal Abscess in Severe Combined Immunodeficiency Probably Due to BCG Vaccine

Pınar GÜR ÇETINKAYA 1, Deniz ÇAĞDAŞ 2, Uğur ÖZÇELIK 3, İlhan TEZCAN 2,

1 Department of Pediatric Allergy and Immunology, Hacettepe University, School of Medicine, Ankara, Turkey
2 Department of Pediatric Immunology, Hacettepe University, School of Medicine, Ankara, Turkey
3 Department of Pediatric Pulmonology, Hacettepe University, School of Medicine, Ankara, Turkey

DOI: 10.21911/aai.491
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Severe combined immunodeficiency (SCID) is characterized by the impairment of T cells with or without B and Natural Killer (NK) cells, leading to recurrent bacterial and viral infections. Although hematopoietic stem cell transplantation (HSCT) is the curative treatment of SCID, many complications and especially infections can develop afterwards. Herein, we report a seven-month-old girl who was diagnosed with SCID and underwent HSCT from HLA-full-matched related donor. However, the patient was complicated with retroperitoneal abscess and chest wall granuloma following HSCT, probably due to the Bacillus Calmette Guerin (BCG) vaccine. The symptoms of the patient were controlled with anti-tuberculosis therapy and intravenous antibiotics.

Keywords : Hematopoietic stem cell transplantation, mycobacterium tuberculosis, primary immunodeficiency, retroperitoneal abscess, severe combined immunodeficiency