Asthma Allergy Immunology

Asthma Allergy Immunology

2010, Vol 8, Num, 2     (Pages: 112-116)

A case of sustained eosinophilia and adenocarcinoma of the prostate: natural defense or coincidence?

Özgür KARTAL 1, Mustafa GÜLEÇ 1, Sami ÖZTÜRK 2, Ahmet Zafer ÇALIŞKANER 1, Osman ŞENER 1,

1 Division of Allergic Diseases, Gulhane Military Medical Academy, Ankara, Turkey
2 Department of Allergic Diseases, Haydarpasa Training Hospital, Gulhane Military Medical Academy, Istanbul, Turkey

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Eosinophils are usually considered as an end-stage cell, involved only in host protection against parasites or allergic diseases. However, there is accumulating evidence showing that eosinophils are multifunctional leukocytes involved in several immunological responses. In this report, a patient with persistent eosinophilia, who was finally diagnosed as prostatic adenocarcinoma, is presented and discussed. While any tumor can induce eosinophilia, prostate carcinoma-related eosinophilia is quite rare, according to the current medical literature. Moreover, some remarkable findings about eosinophils and prostate tumor cells, other than the recently reported ordinary `eosinophil-tumor cell` interactions, are also highlighted.

Keywords : Prostate cancer, prostatitis, prostate specific antigen, eosinophil, eosinophilia, cadherin