Asthma Allergy Immunology

Asthma Allergy Immunology

2012, Vol 10, Num, 1     (Pages: 019-024)

Serum leptin levels among 6-16-year-old children with asthma and obesity

Ayşe YENİGÜN 1, Özgün UYGUR 2, Dilek YILMAZ 1, Aslıhan KARUL BÜYÜKÖZTÜRK 3,

1 Department of Children’s Health and Diseases, Faculty of Medicine, Adnan Menderes University, Aydın, Turkey
2 Department of Children’s Health and Diseases, Faculty of Medicine, Ege University, Izmir, Turkey
3 Department of Biochemistry, Faculty of Medicine, Adnan Menderes University, Aydın, Turkey

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Objective: The incidence of asthma is slightly increasing. In regions where prevalence of asthma is getting higher, there is a tendency for an increase in obesity. The aim of this study is to evaluate the relation between serum leptin levels, pulmonary function tests and serum total IgE levels among 6- 16-year-old-children with asthma and obesity.

Materials and Methods: There were 44 children included in the study (mean age 10.2 ± 2.36 years). Totally 11 asthmatic (3 female, 8 male), 12 asthmatic obese (3 female, 9 male) and 9 obese (7 female, 2 male) children were selected. Control group was consisted of 12 healthy (6 female, 6 male) children. Body mass index, pulmonary function tests, serum total IgE levels and serum leptin levels were calculated.

Results: Interestingly; there was a significant relation between PEF levels and serum leptin levels (p= 0.016) but no relation was found between leptin levels and FEV1, FVC, FEV1/FVC. In the study; no positive effect of inhale steroid on leptin was present (p> 0.05).

Conclusion: Every new study about leptin brings together new data about the subject. In this point of view because of the positive relation between PEF and serum leptin levels, it would be necessary to measure serum leptin level beside PEF in acute and chronic asthma therapy.

Keywords : Leptin, asthma, obesity, children