Chronic Granulomatous Disease Presenting with Invasive Aspergillosis and Hypogammaglobulinemia

Authors

  • Sevgi Keleş
  • Ahmet Soysal
  • Cevdet Özdemir
  • Aarif O. Eifan
  • Nerin Bahçeciler
  • Mustafa Bakır
  • Işıl Barlan

Keywords:

Granulomatous disease, chronic, child, hypogammaglobulinemia, invasive pulmonary aspergillosis, aspergillosis

Abstract

Chronic granulomatous disease (CGD) is a rare disorder with the unifying characteristics of severe predisposition to bacterial and fungal infections, impaired ability of phagocytic leukocytes to produce microbicidal oxygen metabolites and failure of these cells to kill certain microorganisms. Aspergillus spp. are the most common fungal pathogens in these patients. Cranial aspergillosis is a rare presentation with a high mortality rate. Immunoglobulin levels of CGD patients are usually normal or elevated. We herein describe a five-year-old boy with CGD presenting with disseminated aspergillosis and hypogammaglobulinemia (low IgA and IgG).

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Published

2016-12-04

How to Cite

1.
Keleş S, Soysal A, Özdemir C, Eifan AO, Bahçeciler N, Bakır M, Barlan I. Chronic Granulomatous Disease Presenting with Invasive Aspergillosis and Hypogammaglobulinemia. AAI [Internet]. 2016 Dec. 4 [cited 2022 Jan. 24];7(3):189-93. Available from: https://aai.org.tr/index.php/aai/article/view/330

Issue

Section

Case Reports