Relationship Between Hypogammaglobulinemia and Severity and Frequency of Wheeze

Authors

  • Erdem Topal Division of Pediatric Allergy and Immunology, Department of Pediatrics, Inonu University, Faculty of Medicine, Malatya
  • Mehmet Halil Çeliksoy Division of Pediatric Allergy and Immunology, Department of Pediatrics, Ondokuz Mayıs University, Faculty of Medicine, Samsun
  • Ferhat Çatal Division of Pediatric Allergy and Immunology, Department of Pediatrics, Inonu University, Faculty of Medicine, Malatya
  • Recep Sancak Division of Pediatric Allergy and Immunology, Department of Pediatrics, Ondokuz Mayıs University, Faculty of Medicine, Samsun

Keywords:

Wheezing, hypogammaglobulinemia, asthma, child

Abstract

Objective: Several previous studies have assessed immunoglobulin and IgG subclass levels in children with recurrent wheezing. We aimed to determine whether a relationship exists between hypogammaglobulinemia and severity and frequency of wheeze in preschool children with recurrent wheeze.

Materials and Methods: Our study population was children aged 6 months to 5 years who we were monitoring for recurrent wheeze in our clinics. We divided these children into two groups; those who have frequent and severe attacks (group one, n= 86), and those who have rare and mild attacks (group two, n= 67). We also established a control group consisting of healthy children of the same age (group three, n= 75). We assessed serum immunoglobulin levels, peripheral blood eosinophil count and performed a skin-prick test.

Results: Th ere was no diff erence between groups in terms of median age, wheezing phenotype, comorbid atopic disease, parental asthma history, peripheral blood eosinophilia, and hypogammaglobulinemia (p> 0.05). However, there was a signifi cant relationship between being male (p< 0.001), having the fi rst attack of wheezing at an earlier age (p< 0.001), and having frequent and severe wheezing. When we compared the three groups, we found no diff erence between the mean serum IgA level (p= 0.469), serum IgG level (p= 0.211), and serum IgM level (p= 0.831). We found hypogammaglobulinemia in three patients (3.5%) in group one, in two patients (3%) in group two, and in four patients (5.3%) in group three; we found no statistically signifi cant diff erence between groups (p= 0.744).

Conclusion: Th e serum immunglobulin levels of preschool children with frequent and severe wheezing attacks are similar to those of healthy preschool children.

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Published

2015-05-15

How to Cite

1.
Topal E, Çeliksoy MH, Çatal F, Sancak R. Relationship Between Hypogammaglobulinemia and Severity and Frequency of Wheeze. AAI [Internet]. 2015 May 15 [cited 2022 Jan. 24];13(1):21-5. Available from: https://aai.org.tr/index.php/aai/article/view/103

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Section

Research Articles