Pityriasis Iichenoides is a rare cutaneous disorder of clearly unknown etiology and speculated to be an infl ammatory response triggered by many infectious agents. We report a case of pityriasis lichenoides et varioliformis acuta (PLEVA) in a 7 year old boy. Lesions occurred abruptly aft er administration of combined diphtheria, tetanus, acellular pertussis and inactivated polio vaccine (DTaP/ IPV). We want to emphasize that our case is the fi rst case report associated with this vaccine in literature and it is successfully treated with clarithromycin.