Asthma Allergy Immunology

Asthma Allergy Immunology

2019, Vol 17, Num, 3     (Pages: 169-171)

An Indolent Cause of Recurrent Anaphylaxis with NSAIDs: Systemic Mastocytosis

Gökhan AYTEKIN 1, Sıddıka FINDIK 2, Fatih ÇÖLKESEN 1, Eray YILDIZ 1, Ahmet Zafer ÇALIŞKANER 1,

1 Department of Internal Medicine, Division of Clinical Immunology and Allergy, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey
2 Department of Pathology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey

DOI: 10.21911/aai.447
Viewed: 269
 - 
Downloaded : 111

Systemic Mastocytosis (SM) is one of the subtypes of mast cell disorders. Patients with SM suffer from flushing, abdominal cramps and hypotension. It may also cause unexplained and recurrent anaphylactic episodes sometimes. The secretion of mediators can be triggered by various factors.

Non-steroidal anti-inflammatory drugs (NSAIDs) are extensively used for their analgesic, antipyretic and anti-inflammatory properties, and they are one of the most commonly prescribed drugs in the world. On the other hand, they may cause a group of adverse reactions, ranging from mild reactions like gastritis to life-threatening allergic reactions like anaphylaxis.

In this paper, we report a patient who had multiple severe adverse reactions against NSAIDs and was referred to our clinic to find a safe alternative NSAID. She was eventually diagnosed with Indolent SM (ISM) when she was evaluated with all of her systemic complaints and symptoms.

Keywords : Systemic mastocytosis, Anaphylaxis, NSAIDs