Biological agents, widely used in the treatment of oncologic, immunologic, and rheumatologic diseases, have long-term effects in reducing mortality rates and disease burden. Targeted biological agents are of great importance due to their higher efficacy and lower side effects. For patients with a history of hypersensitivity reactions or at risk of developing such reactions to these agents, drug desensitization is considered an appropriate treatment option.

In this case report, Ixekizumab was successfully administered to a 53-year-old female patient with a history of allergies to several biological agents through desensitization. The drug was given without premedication, using three different solutions in a 7-step protocol over 90 minutes. This process was successful despite the patient`s previous hypersensitivity reaction to Ixekizumab.