Asthma Allergy Immunology
Asthma Allergy Immunology

Asthma Allergy Immunology

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Successful Desensitization in a Pediatric Patient with Cytarabine Anaphylaxis

Funda AYTEKIN GÜVENIR 1, Zeynep ŞENGÜL EMEKSIZ 1, Emre Sefa GÜLTEKIN 2, Zeliha GÜZELKÜÇÜK 2, Namık Yaşar ÖZBEK 2, Emine DIBEK MISIRLIOĞLU 1,

1 Department of Pediatric Allergy/Immunology, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Türkiye
2 Department of Pediatric Hematology/Oncology, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Türkiye

DOI: 10.21911/aai.2025.658
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Cytarabine (ARA-C) is a chemotherapeutic agent used in the treatment of hematologic malignancies. Although infusion reactions are generally observed with ARA-C, IgE and non-IgE-mediated hypersensitivity reactions have also been reported.

Anaphylaxis was observed on the 3rd dose of ARA-C treatment in a 17-year-old patient diagnosed with acute myeloid leukemia. There was no alternative treatment option for his malignant disease, and we decided to conduct ARA-C desensitization.

We would like to describe a successful desensitization protocol in a pediatric patient who experienced anaphylaxis during ARA-C infusion.

Keywords : Desensitization, anaphylaxis, cytarabine (ARA-C)
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