Asthma Allergy Immunology

Asthma Allergy Immunology

2020, Vol 18, Num, 1     (Pages: 010-015)

Role of Single Nucleotide Polymorphisms of Mammaglobin-A Gene in Nasal Polyposis: A Case Control Study

Işılay ÖZ 1, Sibel ÖZDAŞ 2, Sibel BAŞTIMUR 3, Talih ÖZDAŞ 3, Sami Engin MUZ 3, Huntürk ATILLA 3, Kenan KURT 3, Selim ERBEK 1,

1 Department of Otorhinolaryngology, Başkent University School of Medicine, Ankara, Turkey
2 Department of Molecular Biology, Hacettepe University Faculty of Science, Ankara, Turkey
3 Department of Otorhinolaryngology, Ankara Yenimahalle Training and Research Hospital, Ankara, Turkey

DOI: 10.21911/aai.456
Viewed: 176
Downloaded : 69

Objective: Nasal Polyposis (NP) is a chronic inflammatory disease and genetic factors play an important role in the pathophysiology. Mammaglobin-A (MGA) gene expression was significantly higher in patients with NP and chronic rhinosinusitis compared to normal mucosa. In the present study, we investigated the relationship between single nucleotide polymorphisms (SNPs) in the MGA gene and nasal polyposis in the Turkish population.

Materials and Methods: A total of 87 patients diagnosed with NP and 60 healthy volunteers were enrolled in the study. Genotypes of MGA promoter SNPs c38C>G, c.21C >T, c55+186G>A and c.243+230A>T were determined by light SNP ASSAY after real time PCR analysis using genomic DNA samples obtained from the peripheral blood samples of all participants.

Results: A total of 87 NP patients, 51 male and 36 female, with a mean age of 38.18±9.5 years were included in the study. No significant difference was determined at all positions c38C>G, c.21C >T, c55+186G>A and c.243+230A>T in nasal polyp patients compared to controls with and without allergic rhinitis (AR).

Conclusion: MGA gene c38C> G, c.21C> T, c55 + 186G> A, and c.243 + 230A> T genotypes did not appear to be associated with susceptibility to NP with and without AR in our study population.

Keywords : Allergic rhinitis, gene expression, mammaglobin-A, nasal polyps, single-nucleotide polymorphism