Asthma Allergy Immunology

Asthma Allergy Immunology

Kimura Disease as a Rare Cause of Eosinophil and Total IgE Elevation

Fatma Merve TEPETAM 1-2, Seyma OZDEN 1, Tugce YAKUT 2, Selver Seda MERSIN 3,

1 Department of Immunology and Allergy, University of Health Sciences, Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Türkiye
2 Department of Immunology and Allergy, Koç University Hospital, İstanbul, Türkiye
3 Department of Immunology and Allergy, Muğla Sıtkı Koçman University Hospital, Muğla, Türkiye

DOI: 10.21911/aai.2024.457
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Kimura disease (KD) is a rare, chronic, inflammatory disorder of unknown etiology characterized by the development of subcutaneous lymphoid masses, usually in the head and neck region; regional lymphadenopathy; peripheral eosinophilia; and elevated levels of serum IgE. KD has been described in China and Japan as `eosinophilic hyperplastic lymphogranuloma` or `atypical granulation associated with hyperplastic abnormalities in the lymphoid tissue`. The precise prevalence and incidence and the pathogenesis of KD are unknown. Trauma, infection, an IgE-mediated hypersensitivity reaction, or autoimmune processes have been postulated as possible causes. In this article, we aimed to present a patient who was investigated with elevated serum total IgE and eosinophils and diagnosed as Kimura disease in the light of the current literature.

Keywords : Kimura disease, eosinophilic hyperplastic lymphogranuloma