Asthma Allergy Immunology

Asthma Allergy Immunology

A Rare Case Report: ICOS and WIPF1 Mutation Together in A Patient

Elif ARIK 1, Ozlem KESKIN 1, Mahmut CESUR 1, Ercan KUCUKOSMANOGLU 1, Ahmet BASTURK 2,

1 Department of Pediatric Allergy and Immunology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey
2 Department of Pediatric Gastroenterology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey

DOI: 10.21911/aai.2024.449
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The inducible T-cell costimulator (ICOS) deficiency was first described in 2003. Autosomal re-cessive inherited ICOS deficiency is classified as combined immunodeficiency (CID) and has a wide clinical spectrum including hypogammaglobulinemia, recurrent infections, enteropathies, autoimmunity, lymphoproliferation, and malignancy. WAS/WASL Interacting Protein Family Member 1 (WIPF1) mutation causes WIP deficiency, characterized by thrombocytopenia, immu-nodeficiency, and eczema. Here, we aimed to present a patient with coexisting ICOS and WIP de-ficiency.

Keywords : ICOS, WIPF1, CVID, child