Asthma Allergy Immunology

Asthma Allergy Immunology

Successful Oral Acetazolamide Desensitization in a Pediatric Patient with Anaphylaxis

Sibel KAPLAN SARIKAVAK 1, Selami ULAS 1, Ozge TURKYILMAZ UCAR 1, Ihsan KAFADAR 2, Zeynep OZ 2, Pinar GOKMIRZA OZDEMIR 1, Cigdem AYDOGMUS 1, Mehmet Halil CELIKSOY 1,

1 Department of Pediatric Allergy and Immunology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey
2 Department of Pediatric Neurology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey

DOI: 10.21911/aai.2024.464
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Anaphylaxis typically occurs due to immunological mechanisms involving IgE, IgG, or complement-mediated responses, but nonimmunological mechanisms can also contribute to the development of anaphylaxis by triggering mast cell and basophil degranulation. In cases where alternative treatment options are unavailable, or when the use of a specific drug is essential, a desensitization protocol should be considered. In this context, we present a successful oral desensitization protocol in a pediatric patient who experienced anaphylaxis after taking acetazolamide orally.

Keywords : Acetazolamide, anaphylaxis, desensitization, children