Netherton syndrome is a rare disease with autosomal recessive inheritance and characterized by the triad of congenital ichthyosiform erytroderma, trichorrhexis invaginata, and atopic manifestations. We herein report a patient who presented to the pediatric allergy and clinical immunology outpatient clinic with signs of ichthyosis, multiple food allergy, anaphylaxis, hypereosinophilia, and hyperimmunoglobulinemia E (hyper-IgE), and was diagnosed as having Netherton syndrome.