Stevens-Johnson syndrome is a serious systemic disorder in which there are fever, vesicobullous lesions involving the skin and mucous membranes. It can result as an immune response to an antigen or as a drug reaction. Most often it is considered as an allergic reaction. It is a self-limiting condition which responds to immediate management or may result in fluid loss, sepsis and death. There is no specific treatment for Stevens-Johnson syndrome. Suspected drug discontinuation and supportive therapy is the first step in treatment of Stevens- Johnson. Systemic steroid use in the treatment of Stevens-Johnson syndrome is a controversial issue. Here, we present a case of Stevens-Johnson syndrome who responded well to the treatment with systemic steroids.