Asthma Allergy Immunology

Asthma Allergy Immunology

2012, Vol 10, Num, 2     (Pages: 100-103)

Are ACE inhibitors realy safe in the patients receiving venom immunotherapy?

Mehmet ÜNSEL 1, F. Ömür ARDENİZ 1, Nihal METE 1, Aytül Z. SİN 1,

1 Division of Immunology and Allergy, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, Turkey

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Few reports have been notified regarding systemic allergic reactions in patients being put on angiotensin corverting enzyme (ACE) inhibitor during the course of venom immunotherapy. There have been conflicting suggestions with respect to ACE inhibitor use during the course of VI in the literature. There is no consensus report clarifying this issue in the clinical practice. Herein we reported a case experienced anaphylaxis after being put on angiotensin corverting enzyme (ACE) inhibitor and beta-blocker therapy by reason of heart attack while receiving venom immunotherapy injections with Apis mellifera in the maintenance phase and discussed the likely causitive factors.

Keywords : Venom immunotherapy, ACE inhibitor, anaphylaxis, beta-blocker