Melkersson-Rosenthal syndrome (MRS) is a rarely encountered clinical entitiy characterized with the triad of facial nerve palsy, recurrent episodes of orofacial oedema and fissured tongue. The etiology of MRS is not yet clearly understood. We report a case of MRS with classical triad who also received diagnosis of autoimmune hypothyroidism pointing out that investigating autoimmune diseases including autoimmune hypothyroidism in patients with MRS is important.