Asthma Allergy Immunology

Asthma Allergy Immunology

2015, Vol 13, Num, 2     (Pages: 071-075)

The evaluation of allergic reaction in patients with egg allergy after measles-mumps-rubella vaccination

Murat ÇAPANOĞLU 1, Tayfur GİNİŞ 1, Ayşe Betül BÜYÜKTİRYAKİ 1, Müge TOYRAN 1, Emine VEZİR 1, Can Naci KOCABAŞ 1, Emine DİBEK MISIRLIOĞLU 1,

1 Ankara Çocuk Sağlığı ve Hastalıkları Hematoloji Onkoloji Eğitim ve Araştırma Hastanesi, Çocuk Allerji ve İmmünoloji Kliniği, Ankara, Türkiye

DOI: 10.5578/aai.9215
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Downloaded : 444

Objective: Measles mumps rubella vaccine is considered as a potential allergen in children with egg allergy and although it is suggested to adminester the vaccine without any evaluation in egg allergic patients, parents and health caregiver share doubts about vaccination. Aim of this study was to evaluate the clinical reactions in patients with egg allergy aft er MMR vaccine administration as a single dose without performing a skin test.

Materials and Methods: Patients who were followed with diagnosis of egg allergy in our clinic between June 2013 and November 2014 were included in this study. Each patient received MMR vaccine subcutaneously as single dose without performing skin test with vaccine at age 9 and/or 12 months of age. Patients were followed up for 1 hour at clinic under supervision.

Results: Fift y-eigth patients with egg allergy received 110 dose MMR vaccine during study. Th e mean age was 17.8 ± 4.4 (9-26) months and 63.8% (n= 37) were male. Th e mean age at diagnosis was 6.7 ± 2.7 (1-13) months. Forty eigth patients (82.8%) had atopic dermatitis, 8 patients (13.8%) had urticaria, one patient (1.7%) had anaphylaxis and one patient (1.7%) had food protein induced enterocolitis induced by egg allergy. Urticaria occurred aft er application of vaccine in a patient who had egg associated urticaria and atopic dermatitis. Th e frequency of reaction aft er vaccination was found as 0.9% (1/110) dose. Aft er 3 months, skin test with MMR vaccine was found negative. Th en, the patient received MMR vaccine again as a single dose and there was not any reaction.

Conclusion: MMR vaccine can be administered as single dose without skin test to patients with egg allergy, especially patients who have atopic dermatitis. However, intervention equipment for possible allergic reaction should be available in center where the vaccines are applicated.

Keywords : Anaphylaxis, atopic dermatitis, measles mumps rubella vaccine, egg allergy, urticaria